Assistant professor
Stanford
My scientific interest is to understand, develop, and apply the concept of metabotherapy – using metabolites as vehicles and targets to prevent and treat disease. While the roles of metabolites in physiology are multifaceted and exciting, a large fraction of the metabolites in the human body remains unidentified, with their functions still completely unknown. It is my scientific mission to decipher the metabolite code of the human body, letter by letter. My lab primarily focuses on the metabolite landscape of the gastrointestinal tract, where the inside of the body meets the outside. Our recent work has pioneered the idea that diet- and microbiome-derived intestinal metabolites regulate numerous aspects of host physiology and can be harnessed for therapeutic approaches—a concept we now refer to as metabotherapy. We are applying this strategy to intestinal inflammation, infection, and colorectal cancer. Our current work builds on our previous studies (Levy et al., Cell 2015 and Cell 2016, Dmitrieva-Posocco et al., Nature, 2022, Kindschuh et al., Nature Microbiology, 2023, Schneider et al., Cell, 2023) and aims to make a significant leap forward in our conceptual understanding of eukaryotic-prokaryotic communication networks in the gastrointestinal tract.
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