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Final Program


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Symposium

Clinical Practice

Complementary Integrative Rehabilitation Medicine

Pain Rehabilitation

Harnessing Stem-cell Derived Exosomes for Musculoskeletal Regenerative Health 1925

Wednesday, October 29, 2025
2:30 PM - 3:30 PM  
Location:  ROOM: Conference Room 4A >>> DIRECTIONS Fourth Floor >>> From the Main Elevator Bank, proceed left. Room 4A is at the end of the corridor, after taking a right just before Room 4-D.

    Corresponding Presenter(s)

  • Jeff Gross, MD

    Chief Medical Officer
    ReCELLebrate
    Henderson, NV, United States

Stem-cell-derived exosomes are being demonstrated as a powerful tool in musculoskeletal regenerative medicine, offering a novel, cell-free alternative to traditional stem cell therapies and a much less invasive treatment when compared to surgical endeavors for tissue repair, and functional restoration. These extracellular vesicles (exosomes) play a crucial role in cell signaling, tissue repair, inflammation modulation, and angiogenesis, making them an attractive therapeutic but non-surgical option to simtulate chondrogenesis for conditions such as osteoarthritis, tendinopathies, and degenerative joint changes. Explained are the biological mechanisms of exosomes, highlighting their potential to reduce inflammation, restore cellular function, accelerate reparative healing, enhance joint maintenance and lubrication, and optimize patient outcomes. This lecture covers clinical applications and outcomes, recent scientific advancements, therapeutic protocols, and regulatory considerations.

References:
Hernigou P et al: Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow up.  Int Orthop 2021 Feb: 45(2):365-373

Gross J: Spinal Regenerative Medicine, Chapter 12 in Musculoskeletal Ultrasound-Guided Regenerative Medicine, Miedany, Y (ed) Springer, 2021.

Learning Objectives:

  • Upon completion, the participant will have an understanding of regenerative orthobiologics with a specific focus on stem cell derived exosomes for use in cartilage regeneration.
  • Upon completion, the participant will be able to understand how stem cell derived exosomes are currently applicable without surgery to help those with degenerative joint clinical issues.
  • Upon completion, the participant will be able to discuss the nature of regenerative options in and informed way if the need arises to refer clients for additional non-surgical tools which enable one's own biology to help rehabilitate joint and mucsculoskeletal conditions