Standing Impairs Neural Efficiency in Alzheimer’s Disease: ERP Evidence of Cognitive-motor Interference

Presenting Author(s)

Sodiq O. Fakorede, B.Tech (he/him/his)

Graduate Assistant/PhD Candidate
University of Kansas Medical Center

Kai Cheng, n/a

Student
University of Kansas Medical Center
LP

Lydia Pemberton

Student
University of Kansas Medical Center
KL

Ke Liao, PhD

Research Fellow
The University of Kansas Medical Center
Jacob J. Sosnoff, PhD

Professor
University of Kansas Medical Center
Jeff M. Burns, MD, MS

Co-Director, KU Alzheimer's Disease Research Center, SOM-Kansas City Division Director, Neurocognit
The University of Kansas Medical Center
Hannes Devos, PhD (he/him/his)

Associate Professor
University of Kansas Medical Center

Explain the concept of cognitive-motor interference by describing how a change in postural demand (from sitting to standing) differentially affects neural efficiency in individuals with Alzheimer's Disease (AD) compared to Healthy Older Adults (HOA).
Describe the study's primary finding regarding the P3 event-related potential (ERP) component, specifically how P3 latency changed for both the AD and HOA groups when performing a cognitive task in a standing versus a sitting position.
Analyze the clinical implications of the study's conclusion, discussing why P3 latency could serve as a sensitive biomarker for postural instability in AD, even when behavioral performance like accuracy and reaction time shows no significant decline.