EX-CIPN: A Phase I Trial of a Remote Exercise-based Rehabilitation Intervention to Treat Persistent Chemotherapy-induced Peripheral Neuropathy

Tuesday, October 28, 2025

4:30 PM - 4:45 PM

Location: ROOM: Waldorf Room >>> DIRECTIONS: Third Floor >>> From the Main Elevator Bank, proceed left. Waldorf is the first room on your left.

Presenting Author(s)

Eric M. Antonen, MSc

PhD Student
University of Toronto and Princess Margaret Cancer Centre, University Health Network
Toronto, ON, Canada

Slides Slides

Non-presenting Author(s)

MN

Michelle Nadler, MD, MSc, FRCPC

Breast Medical Oncologist
Princess Margaret Cancer Centre, University Health Network
Toronto, Ontario, Canada
David M. Langelier, MD, MSc, FRCPC, Dip CSCN (EMG) (he/him/his)

Assistant Professor and Clinical Teacher
University of Calgary
Calgary, Alberta, Canada
Kristin L. Campbell, BSc, PT, PhD

Professor
University of British Columbia
Vancouver, British Columbia, Canada
DF

David Flamer, MD FRCPC

Physician, SHS Pain Services Medical Director
University of Toronto
Toronto, Ontario, Canada
Scott Capozza, MS, PT

Physiotherapist
Smilow Cancer Hospital at Yale Cancer Centrr
Oxford, Connecticut, United States
LA

Lisa Avery, PhD, MSc, BEng.

Principal Biostatistician and Assistant Professor
University Health Network; University of Toronto
Toronto, Ontario, Canada
Kelcey A. Bland, BHK, MSc, PhD

Postdoctoral Fellow
University of British Columbia
Vancouver, British Columbia, Canada
Scott T. Leatherdale, PhD, FAAHB

Professor
University of Waterloo
Waterloo, Ontario, Canada
Jennifer M. Jones, PhD

Senior Scientist and Director of Cancer Rehabilitation and Survivorship
UHN/Princess Margaret Cancer Centre
Toronto, Ontario, Canada

This presentation will discuss a pilot study done to determine the feasibility, acceptability, and safety of a virtual exercise-based rehabilitation program for chemotherapy-induced peripheral neuropathy (CIPN) and to estimate its effects on CIPN symptoms and physiologic outcomes. The program incorporates aerobic, resistance, and neuropathy specific exercise along with remote monitoring and health coaching calls. The results support the feasibility, acceptability, and safety of the program and show encouraging preliminary effects of the program on CIPN symptoms, CIPN-related disability, strength, and functional capacity.

Learning Objectives:

Upon completion, participant will be able to define what CIPN is and how it affects cancer survivors.
Upon completion, participant will be able to describe how the EX-CIPN program and study were designed to help with incorporation into rehabilitation practice.
Upon completion, participant will be able to understand the results and conclusions of the EX-CIPN pilot study and the potential benefits to the CIPN population.